You'll now be able to see real-time price and activity for your symbols on the My Quotes of Nasdaq.com. While M&A was plentiful in 2018 and 2019, and even held up during a year gripped by the coronavirus pandemic, 2021 was much quieter. Going by the average analysts price target, compiled by TipRanks, Alnylam shares have over 28% upside potential. 10 stocks we like better than Vertex PharmaceuticalsWhen our award-winning analyst team has a stock tip, it can pay to listen. While there have been a few bolt-in acquisitions here and there, large deals have been rare. I think these would be great for the investors, mostly because I think maybe their valuations are a little inflated. . Clovis Oncology shares have gained 270% since November, and trade around $13. Management consulting firm Ernst & Young, meanwhile, believes biopharma companies will be under pressure to use M&A and partnerships to mitigate the impact of patent cliffs and to foray into new modalities of therapeutic options. The FDA has accepted the new drug application for adagrasib in NSCLC, with a PDUFA goal date of Dec. 14, 2022. RTTNews.com for Big pharma companies will be keen on picking up biotech stocks for deal sizes in the $5 billion to $15 billion range. PwC also expects large-sized deals, valued at $50 billion or more, for diversifying into adjacent therapeutic areas. Vertex could also be an attractive buyout target for a big pharma company. Nasdaq We first began to hear acquisition rumors in Antares in late 2011. 2023 InvestorPlace Media, LLC. On June 14, Alnylam announced that the FDA approved its RNAi drug AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults, a rapidly progressive and fatal disease with debilitating polyneuropathy manifestations for which there are few treatment options. It is running mid-stage clinical trials of the drug, in combination with bezafibrate, in PBC, late-stage studies in non-alcoholic steatohepatitis (NASH) and a mid-stage study in biliary atresia. The reason is that their deal is for an over the counter product that Pfizer has in its inventory. Tripos International bought out Pharsight for $57M. Then I'll throw one more out -- Vertex (VRTX 3.67%) buying CRISPR Therapeutics (CRSP 3.66%). An early-stage asset, codenamed BMN 307, is mired in trouble. Ra Medical Systems (NYSE American: RMED) announces a realignment of its board of directors in conjunction with the recently announced merger with Catheter Precision, Inc. David Jenkins has joined the board as Executive Chairman and James Caruso has been named director. Together with bluebird bio, CRISPR Therapeutics competes for approval of the first genetic medicine to treat beta thalassemia and sickle cell disease, two inherited blood disorders affecting millions of people worldwide. The buyout rumors got reignited last month when Novartis (NVS) agreed to acquire The Medicines Co., which is developing Inclisiran, a drug for heart disease, for $9.7 billion. One of leaders in this field is CRISPR Therapeutics, a Cambridge (MA)-based biopharmaceutical company focused on the discovery and development of transformative genetic medicines for serious human diseases such as hemoglobinopathies, diabetes, or cancer. The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc. 2023, Nasdaq, Inc. All Rights Reserved. Acquisitions are back in full swing in the sector. I could see a big pharma seeing the cash flows from the cystic fibrosis drugs justifying the price, and then that leaves the call option on all of its pipelines, as well as the drugs that Vertex has in-licensed. Let's take a look at some of the biotech companies that have been in the acquisition crosshairs for quite some time. GLOBAL MARKETS-Stocks buoyed by cheery data after BOJ damp squib, Nouriel Roubini: There's a massive disconnect between markets and the Fed, U.S. natgas price slump pushes 'widow maker' toward unusual contango, Germany must speed hydrogen plans this year - gas pipeline group OGE, Ian Bremmer: We're in a hot war with Russia. It expects to grow its revenues by 14% in the next fiscal year. Cash position at the end of the fiscal year was at $1.52 billion. Gene-editing company Crispr (NASDAQ:CRSP) has long been considered as a potential M&A target owing to its promising technology platform and its longstanding partnership with Vertex Pharma (NASDAQ:VRTX). This conference call is no longer online, but the. It remains to be seen if the takeover rumors are just wishful thinking or will turn into reality. Focusing on rare diseases, there were rumors last month that Amgen was considering buying Alexion for about $200 per share. That's the downside there. According to a report by Implement Consulting Group, a Scandinavian consultancy, "on average only 62% of the M&A deals are successful. Are some major acquisitions on the way in the biopharmaceutical industry this year? In 2013, there were reports that Roche was eyeing BioMarin for a possible acquisition. Meanwhile, earlier this month, U.K.-based Elliott Advisors, one of the largest stakeholders in Alexion, urged the company to take a proactive approach and put itself up for sale to maximize the chance of an optimal outcome. Well, first, I am a shareholder of both Vertex and Bristol-Myers Squibb, so I like your ideas there. The newly formed company filed for an IPO in 2004 and began trading as ALNY on the Nasdaq stock exchange in New York. Sold Sepracor to Dainippon Sumitomo: Mr. Adams served as President and Chief Executive Officer of Sepracor Inc. Dainippon Sumitomo bought out Sepracor for $2.6B, or a 48% premium over the current share price. CRISPR Therapeutics CRSP is one of the leading gene-editing companies. Calibre Scientific is pleased to announce the acquisition of Glass Chemicals, a Spanish distributor of scientific consumables, equipment and services for the life sciences, diagnostics, and industrial sectors. Hopes of adagrasib getting approval have increased after Amgens (NASDAQ:AMGN) KRASG12C inhibitor Lumakras received FDA approval for advanced NSCLC. Price as of January 17, 2023, 4:00 p.m. Oncology and gene therapy were the subjects of acquisitions this year. No. Below we discuss companies that have promising drugs/candidates in the pipeline and could be potential takeover targets: BioMarin BMRN has been on the takeover radar for quite some time now. Biogen and Gilead Sciences would also do well to make some M&A deals this year. Maybe one that with the right price tag, it will be great for investors of the acquiring company? If the letter of intent to acquire your company has been signed, you might be asking what happens next. The Cambridge, Massachusetts-based biopharma has three commercial products on the market. Global Blood Therapeutics ( GBT) - $9B. Takeover rumors initially swirled around Clovis Oncology in 2013 when Rubraca, was in clinical trial stage. While oncology and immuno-oncology are the key areas of focus, treatments for rare diseases and gene-editing companies also promise potential, making them lucrative investment areas. (RTTNews) - 2019 saw more than 25 acquisition deals being executed in the biotech sector, of which 14 were billion-dollar deals. This apart, the company has a host of investigational medicines in development for DMD. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Even with a market cap of over $2B, we feel Acadia could fetch as much as $6B if the FDA approves pimavanserin, which could happen in the next 6 to 8 months. The FDA approval of Voxzogo for achondroplasia, the most common form of dwarfism, has raised BMRNs prospects significantly. The Company submitted a Marketing Authorization Application to the. M&A deal flow dwindled in 2021, reflecting stricter antitrust laws. Calyxt, Inc. (Nasdaq: CLXT), a plant-based synthetic biology company, and Cibus, a leader in precision gene editing in agriculture, today announced that both companies have entered into a definitive merger agreement under which Calyxt and Cibus will merge in an all-stock transaction. But I think there's also a good fit on Seagen's pipeline too. Written by Team StockMatusow.com research and writers are: Scott Matusow; Team Leader, owner and founder of StockMatusow.com and Dan Cohen, partner, and independent investor/scientist/inventor/trader and lead contributor at stockmatusow.com. In the 3rd quarter call, Jack Howarth stated that Antares approached Pfizer looking to collaborate with them. Gilead Sciences (GILD -1.00%) also has not been shy about making smaller deals. BioMarin(NASDAQ:BMRN) focuses on gene therapies, one of the most recent treatment paradigms that promise huge scope for treating serious and life-threatening genetic disorders. Otrexyo is a registered trademark of Pfizer. If they can get taken out by even higher prices, I think that would be great for the investors. Last month, Adaptimmune announced that SPEARHEAD-1 trial evaluating afamitresgene autoleucel (afami-cel, formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) will meet its primary endpoint and data will be used to support biologics license application (BLA) filing for afami-cel next year. Copyright After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has tripled the market.*. The number of done deals dropped to 92 from 101 in 2020 and 111 in 2019. Massachusetts-based biotech Leap Therapeutics announced Tuesday that it had entered into a merger deal with the privately-held Flame Biosciences, Inc. Elicio Therapeutics entered into a merger agreement as a wholly-owned subsidiary of Angion Biomedica Co. on Tuesday, becoming a Nasdaq-listed company. One of the hot topics in the biopharmaceutical world are mergers & acquisitions (M&A). To make the world smarter, happier, and richer. Financial Market Data powered by FinancialContent Services, Inc. All rights reserved. The quest behind the drive is to fill potential gaps in the pipeline. Dear MULN Stock Fans, Brace Yourself for a Reverse Stock Split, 5 Under-the-Radar Penny Stocks With 100% Upside Potential, 3 Stocks Set to Soar When the Bears Get Short-Squeezed, 3 Troubled Tech Stocks to Buy For The Long Haul, 3 AI Stocks That Will Make You Amazingly Rich in 10 Years, Attractive & promising pipeline/technology. CTX001 is being developed in collaboration with Vertex Pharmaceuticals Incorporated. Ionis (NASDAQ:IONS) is commercial-stage biopharma developing RNA-targeted therapy using antisense technology that can control gene expression in a cell using antisense oligonucleotides (ASO). Scott has long positions in 3 companies mentioned in this article. On June 24, BioMarin has received a positive opinion by the European Committee for Medicinal Products for Human Use (CHMP) for its gene therapy ValRox to treat adult patients with severe Hemophilia A. Ipsen bought out Tercica for $404M, or a 104% premium over the current stock price. Keith Speights owns shares of Vertex Pharmaceuticals. But there are some deals that Motley Fool contributors Brian Orelli and Keith Speights hope will happen. Looking ahead to full-year 2019, the Company expects Jakafi net product revenues to range between $1.65 billion and $1.68 billion, reflecting 20% to 22% growth over the prior year. Youre reading a free article with opinions that may differ from The Motley Fools Premium Investing Services. Powered by Madgex Job Board Software. Freight. Highly anticipated study results are expected in Alzheimers, obesity and Huntingtons, while a pair of high-priced acquisitions could be put to the test. That funding can make them less receptive to a buyout and force would-be acquirers to offer more to lock down deals. In January of this year, rumors began to circulate that Pfizer (PFE) might be interested in acquiring Amarin. In early 2017, the rumor mill was spinning with whispers of Gilead (GILD) close to acquiring Incyte. There's a company called Adicet Bio (ACET 0.46%), ticker there is ACET, I believe. We'll see if that happens, but I think it would be one of the top megamerger acquisition candidates that are on the market right now. Hunzinger said: Biotech and smaller medical device deals should continue in the first half of the year, with the second half poised for larger deals driven by a need for scale and an expected settling of the regulatory landscape.. This submission marks the first marketing application submission for a gene therapy product for any type of hemophilia. If there's anything we've missed, or any additional information you'd like to see, please reach out and let us know. Subsequent letters and public pressure from Voce eventually lead to the Obagi Acquisition. Places you can follow Scott are: www.stockmatusow.com www.twitter.com/StockMatusow @StockMatusow http://www.facebook.com/TheScottMatusowShow Places to follow Dan are: https://twitter.com/biosleuth. 5. Want the latest recommendations from Zacks Investment Research? Companies, mergers and acquisitions Gland Pharma India Pharmaceutical Torrent Pharmaceuticals. Sold Pharsight Corporation to Tripos International: Mr. Rosen served on the Board of Directors of Pharsight Corporation. The company's portfolio consists of a few commercialized products and multiple clinical and pre-clinical product candidates. Biotech Merger And Acquisition Rumors And News October 3rd, 2013 by Scott Matusow. (2016). BioSpace is covering all the key announcements all week. The database, which shows drugmaker acquisitions that happened since 2018 and were valued at $50 million or more in upfront consideration, will be regularly updated. AcelRx (ACRX). Invest better with The Motley Fool. In this Motley Fool Live video recorded on Jan. 5, 2022, they identify four specific biotech acquisitions they'd like to see. The most recent update provided by the company suggests it may take several quarters for the issue to be resolved. Mergers and acquisition (M&A) activity in India is heating up. Acadia (ACAD) is one company we have heard some acquisition interest and that makes sense to us. Want to Get Richer? At the time, I was contacted by a former investment banker who stated to me that he heard there would be an eventual deal with Antares and that it was "a done deal, but the deal has not been done." In 2003, Alnylam merged with the German pharmaceutical company, Ribopharma AG. BioNTech SE (Nasdaq: BNTX, "BioNTech") and InstaDeep Ltd. ("InstaDeep") today announced that they have entered into an agreement under which BioNTech will acquire InstaDeep, a leading global technology company in the field of artificial intelligence ("AI") and machine learning ("ML"). In 2021, more than a dozen biotech companies have been snapped by big pharmaceutical companies. Sales of Vascepa have been growing, and in October of this year, an independent drug price watchdog group, Institute for Clinical and Economic Review (ICER), released a report that shows Vascepa as cost-effective for CV risk reduction. The downside is that I'm not really sure Vertex wants to get into the CAR-T business, which is basically the other half of CRISPR's clinical pipeline. To make the world smarter, happier, and richer. I don't know. Whether M&A activity continues will have a significant effect on which startups and drug programs get funded and advanced. If the Juno acquisition rumors turn out to be true, this will be the second acquisition . Specifically, Seagen has an anti-TIGIT antibody. The rumors on Obagi turned out to be correct, as the company was sold last year to Valeant (VRX) for $24 a share. The Motley Fool has a disclosure policy. 13. Bayer announced the acquisition of the global strategic imaging AI platform and solutions provider Blackford Analysis Ltd. Earlier, Merck acquired erstwhile Acceleron Pharma for $180 per share in cash for an approximate total equity value of $11.5 billion to build its rare diseases portfolio. Additional disclosure: Disclaimer: This article is intended for informational and entertainment use only, and should not be construed as professional investment advice. Leading gene-editing biotechs CRISPR Therapeutics and Intellia are likely to be acquired at some point. Speights: Yeah. Enclose phrases in quotes. 10 stocks we like better than Bristol Myers SquibbWhen our award-winning analyst team has a stock tip, it can pay to listen. We have been hearing some strong acquisition rumors concerning AcelRx, much like we heard about Obagi last year. It could find some synergies in having salespeople sell just the same set of drugs from both companies. Editor's note: If tables or values do not display, please try clearing your browser's cache and reloading the page. 9. These deals haven't come cheap, however. The Motley Fool recommends Biogen and Gilead Sciences. One of the catalysts that could work in its favor is deal optimism. I own Seagen. Antares Pharma. Brian, what are some acquisitions that you'd like to. This therapeutic has been licensed to Swiss pharma giant Novartis. Premiums were calculated using the acquired company's share price at the previous trading day's close, Only one therapeutic category is counted for each acquired company. This developer of rare disease drug Soliris has been in acquisition crosshairs since 2016 - with Roche, Pfizer, Novartis and Amgen been reported as potential buyers. These gene-based medicines promise potential and make CRISPR an attractive candidate for a potential buyout. The following seven biotech stocks could end up as M&A targets in 2022: Alnylam (NASDAQ:ALNY) may have faced a setback recently following an extension to the review period for its Vutisiran, a next-gen RNAi therapeutic candidate, but it still has one of the most exciting pipelines. I think that would potentially drive sales of Opdivo. These symbols will be available throughout the site during your session. We first began to hear acquisition rumors in Antares in late 2011. 6. Two exceptions: Amgen's $13.4 billion acquisition of the psoriasis medicine Otezla and Novartis' $3.4 billion acquisition of the dry eye drug Xiidra, which are included for their notable size and importance to the acquirer. His work with diagnostics development give him a strong background in immunology which is leveraged in evaluating immunology focused approaches. 2019 saw more than 25 acquisition deals executed in the biotech sector, of which 14 were billion-dollar deals. After a lengthy drought, could biotech M&A be on the upswing? Get biopharma news like this in your inbox daily. 1125 N. Charles St, Baltimore, MD 21201. Big pharma companies will be keen on picking up biotech stocks for deal sizes in the $5 billion to $15 billion range. Cellectis announced today that Cibus Global LLC and Calyxt, Inc. (NASDAQ: CLXT) (Calyxt), announced that Calyxt and Calypso Merger Subsidiary, LLC, a Delaware limited liability company and wholly-owned subsidiary of Calyxt, entered into an Agreement and Plan of Merger with Cibus and certain other parties named therein (the Merger Agreement), pursuant to which, subject to the terms and conditions thereof, Calyxt and Cibus will merge in an all-stock transaction. Therefore, leading companies such as CRISPR Therapeutics, Intellia Therapeutics, or Editas Medicine might catch the eye of large pharmaceutical companies trying to step into this field and complement their pipeline with CRISPR/Cas9 technology. Brian Orelli: I'd like to see Bristol-Myers Squibb (BMY -0.28%) acquire Seagen (SGEN -1.71%). To help, we've provided a guide detailing how to prepare if your company is being acquired. The results of one of biotech's most polarizing clinical trials, an Alnylam Pharmaceuticals study in a rare disease known as transthyretin amyloidosis cardiomyopathy, are expected imminently. Elicio Therapeutics, a privately-held, clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer and other diseases, has entered into a definitive merger agreement with Angion Biomedica Corp under which Elicio will merge with a wholly-owned subsidiary of Angion in an all-stock transaction.

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