Find advice, support and good company (and some stuff just for fun). This is called the fetal fraction. The reason that your doctor is suggesting an ammio is because studies have shown there is a positive correlation between a low percentage of fetal DNA (i.e. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Have had an earlier screening test that suggests a potential problem. It has to be at least above 4 percent to give a conclusive result. The test can also determine the sex of the fetus. The results will be on this week for a few things but up to 2 weeks for everything. Press J to jump to the feed. We are going to do the quad screen and a detailed ultrasound next week. Your healthcare provider will receive your test results first, then share the results with you. 1997-2023 BabyCenter, LLC, a Ziff Davis company. I have read this is an issue for plus size women and . Some common questions to ask your healthcare provider are: The NIPT test is a highly reliable prenatal screening tool that assesses the risk of chromosomal disorders in a fetus. The quad screening and 12 week ultrasound are more likely to actually work and give back results. All rights reserved. This test can be done beginning at 10 weeks of pregnancy. It can't do genetic risks though. They tell your provider how likely it is that a condition exists. Has anyone had this happen to them or know someone? The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Are you overweight? Note that once you confirm, this action cannot be undone. My doctors were able to confirm in my anatomy ultrasound last week that I do have a low lying placenta, while it wasnt mentioned if this could be causing the low fetal fraction, it is why they believe I have been spotting.. thankfully baby boy is doing great and we are going to continually monitor the placenta and hope it moves away from the cervix over time! When I went back for a second blood draw, they took two tubes of blood. Ocean/sky themed baby girl nursery - finished at 38+ A hilarious moment that made me excited to have my kid. I had a d and c and fell pregnant immediately. Just got my results back yesterday with a BMI of 47. I'll be around 18 weeks by then. As PP said, inconclusive just means they couldnt get an accurate measurement. When I called for test results over a week later, they said they had needed to test the second tube as the first had failed. Hey! Ive heard where some people have a hard time getting results depending on their weight.. the most helpful and trustworthy pregnancy and parenting information. I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. New comments cannot be posted and votes cannot be cast. This is my second baby and I didnt do NIPT with my first. I fully understand your need for answers - I felt exactly the same way and its much better to have a yes/no answer through CVS/amniocentesis than keep guessing etc. My next appt is my anatomy scan and it isnt until Nov 30! Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Wish we did like other pregnancies and skipped the testing! Had my redraw at 13+2, and results have come back the same, inconclusive due to low fetal fraction. I had inconclusive NIPT results. I found out we are having a little girl! It has a heartbeat of 142 but doctor said that hes still very guarded about the pregnancy and strongly advised for the CVS which I will do. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. Overall, NIPT tests produce fewer false positives than other prenatal screenings like the quad screen. Can I ask how your Quad screening went? Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. . Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Another inconclusive result. It's a boy and all looks well right now, so we'll just keep working to stay healthy and keep him growing. I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. Its nerve racking, but I'm hoping to hear some good news soon. DNA makes up a persons genes and chromosomes, and gives healthcare providers a glimpse into the fetuss genetic makeup. Yes with Natera Panaroma, I had inconclusives twice & declined the third redraw. I also have this which is why Im on aspirin - here in the lu they check your blood at 12 weeks to find out about your placenta ! (https://medlineplus.gov/genetics/understanding/testing/nipt/). If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. She didnt suggest further testing. They could have also just waited until 16 weeks for my first blood draw given my weight. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. hYmo6+bDR$EE iZcKZ2,5V~b)%7QGx{8qfs&,9K dbyb:,Xg1cekX3)-l`Gj%SV0H@1#43*a?+V1bM4^%}*&29Li1I=&~~K&a/e2,VaLFEZE]&7_4NO\Vq9z2.U\b1)0[$@'NmY=B(db~O^6jRJfbZ&\fMeY?RPu A]LaR2rt$\.E=_&ShK+05}rYo"&7xJ|10&,*NOop;~\@`zPd40`Qq[BlJMOnsgU*|]yepYE.+yf Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. Are you going to go for a CVS? The NIPT looks at these fragments of fetal DNA in your blood known as cell-free DNA or cfDNA. Low Fetal Fraction. No markers or bright spots. NIPT is about 99% accurate in detecting Down syndrome. This educational content is not medical or diagnostic advice. I didn't do a NIPT (just the NT scan) so no personal experience! I was 164 pre pregnancy and 184 now. I waited 13 days for my Harmony test results and the nurse finally called me back today to tell me my test was inconclusive! Your DNA is inside all of your cells. Were having a boy! I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. He sent me to do echocardiography which also was good and show no signs for pathologies. Most NIPT tests screen for: An extra chromosome causes Down syndrome, trisomy 18 and trisomy 13. I just did a retest last week because mine came back inconclusive!! Its important to note that it takes about 10 weeks for enough fetal DNA to circulate in your blood. The first rest was done around 10 weeks and the second around 14 weeks. My Hi all,I had my first NIPT labs drawn around 10 weeks. Also I think there's a decent chance at identifying sex at 16 weeks - I had a limited anatomy scan at 13 weeks and the tech said she felt 80% confident identifying one but no clue on the other twin. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. Remember, only you and your family can decide whats best for you. If you'd continue the pregnancy regardless of any defects, then I think you can definitely skip the amnio. I had to wait about 10 days for bouth times I did NIPT, only to get inconclusive results. hbbd``b` $X-  H *H2M) u$B@> LW@b!3.|` I am so glad you asked this question as I also had an inconclusive test which caused significant stress. I realize I may have been taking about something different. Were my expectations of postpartum help from my mom Press J to jump to the feed. What is noninvasive prenatal testing and what disorders can it screen for? endstream endobj 73 0 obj <>stream %%EOF yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. I had to do the NIPT test twice. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. And like pp said.I hope your anatomy scan is smooth sailing and you can see that the baby is fine and healthy. Im so so sorry to hear about your loss. We strive to provide you with a high quality community experience. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. I'm 36 weeks now. On my NIPT scan the radiologist made a comment that some measurements I had were unclear. Im going through the exact same. Have a child with a chromosomal abnormality. She said it worked for almost all her patients. HW[o[~G~ mHc}pHV"=. I was also severely anemic and dehydrated due to hyperemesis gravidum. They told me since I am now 16w, I can send the quad screen to test for the trisomies and spina bifida. Ughhhhh. k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. yeah I declined the redraw also and decided to wait. H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Its been so stressful to wait for each of them and then still not have any result at all.. Last reviewed by a Cleveland Clinic medical professional on 10/12/2022. Find advice, support and good company (and some stuff just for fun). Advertising on our site helps support our mission. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. Please whitelist our site to get all the best deals and offers from our partners. Noninvasive prenatal testing: the future is now. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. I am so confused and stressed. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. The accuracy of the test varies by the condition that its checking for. It set my expectations unreasonably high. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Learn more about, Twins & Multiples: Your Tentative Time Table. Im so so very sorry. I have my anatomy scan on Wednesday but Im just so terrified they will give me bad news. Its important to talk to your healthcare provider about what your NIPT is screening for. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Hi friend. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. This time around I used Myriad Prequel, which has a technology that prevents most (maybe all?) First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. My Hi all,I had my first NIPT labs drawn around 10 weeks. I just did the basic scan and blood work covered by Ohip. Maybe call the clinic directly for feedback on how that particular radiologist writes reports. Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. I found out the gender at 16 weeks and BMI was 42 x. Inconclusive NIPT twice? Create an account or log in to participate. Your provider obtains a blood sample through a vein in your arm. u 03-(q}|$05`- H320mf`~e0 * NIPT tests (noninvasive prenatal testing test) use a pregnant persons blood to detect congenital abnormalities in the fetuss DNA. My nipt/panorama/harmony results came back inconclusive both times. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. @Woofwoofbarkbark ya I definitely want to know as early as possible, t13/t18 have such such high chance of late miscarriage etc I need to be prepared if this was a chance To comment on this thread you need to create a Mumsnet account. Please whitelist our site to get all the best deals and offers from our partners. Had first appointment on Monday was told to only gain Best Maternity Underwear for Apron Belly? thank you so much. I had the first done at 13w and second done at 16w. My baby is in under 5th percentile and doc says it looks like there are severe growth restrictions and an abnormally big head/small body ratio so I think that once we have the CVS answer we will have to man up and make decisions as I hate to think that that it may be in pain etc. Taylor-Phillips S, Freeman K, Geppert J, et al. 107 0 obj <>stream I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. I didn't even want them to do that. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. My nipt/panorama/harmony results came back inconclusive both times. So I feel like they wasted both my tries for no reason at all. Fortunately got low risk for chromosomal anomalies Just the baby's sex was inconclusive! I'm now worried something could be wrong with my baby. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Youre little one made it this far, hopefully your little one is strong! Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. I've had the draw twice and thencutoff for weight to be an issue is 250 and I'm 170 so they say that's not the issue :(. NIPT test done twice.with inconclusive results twice. Are you taking aspirin? I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. Same thing happened to me. Inconclusive on gender results? We had issues with our genetic testing as well and I too was super worried! Use of this site is subject to our terms of use and privacy policy. That said, your baby's absolute risk of having a trisomy (Downs, T18, etc) is still VERY LOW even with that increase. So I'm not sure how it was for you. Can I ask how your Quad screening went? Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. Thank you! I've seen a few posts about on this sub from women who had insufficient fetal DNA because of their weight and had to go back for another draw. NIPT testing is optional. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. My doc told me 2 inconclusive tests raises the risk level significantly in my age. 69 0 obj <> endobj Would you get the NIPT test if you were me? Reddit and its partners use cookies and similar technologies to provide you with a better experience. First test taken 10w3days, second taken 13w3days. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. , I agree with PP. I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. Has anyone had this? Also my genetic testing was all negative. Inconclusive NIPT twice. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. You apparently have too much blood for an accurate reading. Be sure to understand what the test screens for and what the results mean so you make an informed decision. Yes, NIPT can be done anytime after 10 weeks of pregnancy. also people mentioned placenta issues above! She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. I ended up asking for a quad screen (it wasnt covered by my insurance but was like $30) to assess risk for trisomy 21, 18 and spina bifida. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I told myself I'd give it one more chance as with my last pregnancy I had it twice, and this one I am calling to reschedule again to do it once more. If noninvasive prenatal testing indicates that the fetus is at risk for a chromosomal disorder, your provider may recommend diagnostic testing. I have a CVS booked for this Thursday which should give me definitive results but both scans didnt look good so far. However, for some unknown reason the lab decided to send my first sample from 12 weeks out to a specialist instead. I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. Cleveland Clinic is a non-profit academic medical center. We just got our results back and have a perfectly healthy eggo. Hey lovely - where are you based? Now it is considered high risk and listed a 1/17 chance of a chromosome issue. Inconclusive NIPT twice! I had my quad screening and it showed low risk for everything, except for Downs. The blood sample is sent to a lab and analyzed for specific congenital disorders. Its a personal choice, and its normal to have questions. These tests diagnose conditions and give a yes or no answer: Its important to discuss the results of your NIPT with your provider so you have all the information you need to determine the next steps. Your cells are constantly dividing and creating new cells. Anyone have wrong gender results? The #1 app for tracking pregnancy and baby growth. I wouldnt have survived with out those ladies. 20062023 BabyCenter, LLC, a Ziff Davis company. Myriad is able to magnify the fetal fraction found in your blood.. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Theyre not sure what caused the inconclusives, but theyre screening and not diagnostics, so it could just be in error. I had a redraw last week and waiting for that to come back. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. Obviously not out of the woods but the good news is all I needed to keep tracking forward with positivity. your experiences with being fat an needing IVF/ICSI? Friend opening my baby items for their own baby. This testing analyzes small fragments of DNA that are circulating in a pregnant woman's blood. I just wish you luck with your anatomy scan and hope all is well! (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). So after 9 weeks of genetic testing and no results we were finally able to get results and everything has turned out ok and we are having a baby boy! Id say if you dont have any family history of issues I bet youll be fine. I wish you well mama! I do think that its such a fighter since it lasted so long fingers crossed its healthy. The first rest was done around 10 weeks and the second around 14 weeks. I was also severely anemic and dehydrated due to hyperemesis gravidum. I had my anatomy scan in December and baby is very healthy and measuring on time! But I was told they like to comment on everything they see based on the technicians scans. Mine came back inconclusive twice. However, they got all the ones they needed for the NIPT which were good. Note that once you confirm, this action cannot be undone. Mine came back inconcl, I was 12 weeks and then took again at 14 1D, I have also had 2 inconclusive results and we are not trying again. We were told they were inconclusive due to low fetal fraction and ended up doing a CVS. I've had he NIPT test twice now and had it come back for low fetal DNA. Oh overall not just gender lol I wish it were twins but I already had a few ultrasounds and saw the single baby. This educational content is not medical or diagnostic advice. I dont have any advice. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! I'm panicking now because I'm so worried. Please specify a reason for deleting this reply from the community. We had two inconclusive NIPT tests (from two different testing companies). Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. My doctor told me to test then and acted as if that wasnt too early. My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? Diagnostic testing may be recommended after you get NIPT test results. They could well be inaccurate- most companies require at least 3%. I had the test done again about 2 weeks later and just got results today. Screening for sex chromosomes can help predict the sex of the fetus and can also screen for differences in the usual number of sex chromosomes. I will likely decline invasive testing like amniocentesis. If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. Has anyone had this happen to them or know someone? Eunice Kennedy Shriver National Institute of Child Health and Human Development. Mumsnet carries some affiliate marketing links, so if you buy something through our posts, we may get a small share of the sale (more details here). I'm so sorry - that happened with me with my previous pregnancy and it was so stressful.

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